Progesterone Therapy for Complete Menopause Care

Progesterone’s Role in HRT

Progesterone is the frequently overlooked half of hormone therapy. For any woman with a uterus taking systemic estrogen, it’s essential — it prevents the uterine lining overgrowth estrogen alone can cause. But its value goes further: progesterone independently improves sleep, eases anxiety, and steadies mood, which is why some women use it even when uterine protection isn’t the driver.

Know Your Progesterone Forms

• ›Micronized progesterone: Bioidentical and preferred in current guidelines. Converts to allopregnanolone, a natural calming and sleep-promoting compound. Sold as Prometrium and generics.
• ›Synthetic progestins: Older HRT components like medroxyprogesterone. They don’t produce allopregnanolone, carry a somewhat different risk profile, and cause mood side effects in some women.
• ›Compounded progesterone cream: Transdermal, personalized dosing used by platforms like Inner Balance. Avoids oral administration, though absorption varies between individuals.

Benefits Beyond Uterine Protection

The Cream-Based Alternative

Inner Balance delivers estrogen and progesterone together in a personalized compounded cream, providing steady transdermal hormone levels without oral dosing. Their model includes ongoing access to hormone specialists, making fine-tuned progesterone adjustments straightforward as your needs change.

How We Rank Progesterone Providers

Our editorial team evaluates each provider across weighted criteria: